Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study

PURPOSE To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). METHODS Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4). RESULTS The mean MD slopes were -0.55/-0.39 (right/left eyes, n = 19) dB/year in the treated group and -1.37/-1.15 (right/left eyes, n = 22) dB/year in the control group (P = 0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values. CONCLUSION Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP.